目录
2019.2-2021.1: 香港大学, 博士后
2010.9-2014.6:浙江大学, 应用生物科学专业,学士
[1] 微生物CRISPR-Cas应用开发
[2] 细菌致病性与耐药性机理研究
[3] 细菌金属离子稳态调控机制研究
[2] 国家自然科学基金青年科学基金项目, 锌胁迫抑制铜绿假单胞菌群体感应系统的作用机制研究, 2022.01 - 2024.12, 主持
[3] 广东省自然科学基金面上项目, 锌离子调控铜绿假单胞菌左氧氟沙星耐药性的分子机制研究, 2023.01 - 2025.12, 主持
[4] 广东省自然科学基金面上项目, 铜绿假单胞菌中双组分系统FleS/FleR对III型分泌系统的调控机制研究, 2022.01 - 2024.12, 主持
[5] 广州市基础与应用基础研究项目, 铜绿假单胞菌中双组分系统FleS/FleR调控生物膜形成的分子机理研究, 2022.04 - 2024.03, 主持
[6] 国家重点研发计划, 华南地区重要粮油作物根际微生物组动态与作物病害发生及关键微生物挖掘, 2022.12 - 2026-11, 参与
[7] 学院新农村发展研究院农村科技特派员服务团队项目, 2021.07 - 2023.07, 参与
[8] 温氏食品集团股份有限公司, 养殖废水通过藻类转化成畜禽饲用产品的关键技术研究与示范, 2023.03 - 2025.12, 参与
[9] Health and Medicine Research Fund (香港医疗卫生研究基金HMRF), Establishing a Pseudomonas aeruginosa-Caenorhabditis elegans embryogenesis model for assessment of the P. aeruginosa virulence and identification of novel virulence factors, 2020.07 - 2023.06, 参与
[2] Xu Z, Park TJ and Cao H*. Advances in mining and expressing microbial biosynthetic gene clusters. Critical Reviews in Microbiology, 2023; 49(1): 18-37.
[3] Lin Q, Huang J, Liu Z, Chen Q, Wang X, Yu G, Cheng P, Zhang L*, Xu Z*. tRNA modification enzyme MiaB connects environmental cues to activation of Pseudomonas aeruginosa type III secretion system. PLoS Pathogens, 2022; 18(12): e1011027.
[4] Liu Z#, Xu Z#, Chen S, Huang J, Li T, Duan C, Zhang L*, Xu Z*. CzcR Is Essential for Swimming Motility in Pseudomonas aeruginosa during Zinc Stress. Microbiology Spectrum, 2022;10(6):e0284622.
[5] Lin S#, Chen S#, Li L*, Cao H, Li T, Hu M, Liao L, Zhang L, Xu Z*. Genome characterization of a uropathogenic Pseudomonas aeruginosa isolate PA_HN002 with cyclic di-GMP-dependent hyper-biofilm production. Frontiers in Cellular and Infection Microbiology, 2022;12: 956445.
[6] Zhou T, Huang J, Liu Z, Lin Q, Xu Z* and Zhang L*. The two-component system FleS/FleR represses h2-T6SS via c-di-GMP signaling in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 2022;88: e01655-21.
[7] Duan C, Cao H, Zhang L* and Xu Z*. Harnessing the CRISPR-Cas systems to combat antimicrobial resistance. Frontiers in Microbiology, 2021;12: 716064.
[8] Zhou T, Huang J, Liu Z, Xu Z* and Zhang L*. Molecular Mechanisms Underlying the Regulation of Biofilm Formation and Swimming Motility by FleS/FleR in Pseudomonas aeruginosa. Frontiers in Microbiology, 2021;12: 707711.
[9] Xu Z, Li Y, Cao H, Si M, Zhang G, Woo P, Yan A*. A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulation. Nucleic Acids Research, 2021;49: e94.
[10] Li Y#, Xu Z#, Han W#, Cao H#, Umarov R, Yan A, Fan M, Chen H, Duarte C, Li L, Ho P, Gao X*. HMD-ARG: Hierarchical Multi-task Deep learning for Annotating Antibiotic Resistance Genes, Microbiome, 2021;9: 40.
[11] Xu Z, Li Y, Li M, Xiang H, Yan A*. Harnessing the type I CRISPR-Cas systems for genome editing in prokaryotes, Environmental Microbiology, 2021;23:542-558.
[12] Xu Z*, Li Y, Yan A*. Repurposing the native type I-F CRISPR-Cas system in P. aeruginosa for genome editing, STAR Protocols, 2020;1: 100039.
[13] Xu Z#, Li M#, Li Y, Cao H, Miao L, Xu Z, Higuchi Y, Yamasaki S, Nishino K, Woo P, Xiang H*, Yan A*. Native CRISPR-Cas-mediated genome editing enables dissecting and sensitizing clinical multidrug-resistant P. aeruginosa, Cell Reports, 2019;29: 1707–1717.
[14] Xu Z, Wang P, Wang H, Yu ZH, Au-Yeung HY, Hirayama T, Sun H, Yan A*. Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli, Journal of Biological Chemistry, 2019;294: 16978–16991.
[15] Xu Z, Yan A*. Multidrug efflux systems in microaerobic and anaerobic bacteria, Antibiotics 2015; 4, 379-396.
[2] 徐泽凌,陈淑珍,刘志晴,徐梓锐,张炼辉。一种基因表达调控系统及其应用,专利号:ZL202210069861.X,申请号:202210069861.X
[3] 徐泽凌,陈淑珍,刘志晴,张炼辉。一种用于基因编辑的组合物及其应用,申请号:202310078804.2
硕士研究生:陈淑珍(2021)、李婷(2021)、徐梓锐(2021)、吴炜妍(2022)、温咏琪(2022)、陈明(2022)、王静宜(2023)、周展图(2023)、莫知凤(2023)
陈淑珍,学院2021-2022学年“范怀忠奖学金”, 一等奖学金;
陈淑珍等,学院2022年“丁颖杯”发明创意大赛,永利集团88304官网一等奖,校级三等奖;
林思颖,2022年“丁颖杯”暨“挑战杯”广东课外学术科技竞赛校内选拔赛, 校级二等奖;
林思颖等,2023年广东省科技创新战略专项资金“攀登计划”,一般项目,1.5万元;
张耀等,2023年大学生创新创业训练计划,国家级立项。